- Interação molecular entre a microbiota intestinal, o sistema renina-angiotensina (SRA) e o sistema calicreína-cininas (SCC).

- O papel da disbiose intestinal na etiologia de doenças cardiometabólicas. 

- Caracterização molecular e funcional da comorbidade entre doenças cardiovasculares e psiquiátricas.

- Identificação e caracterização de novos componentes do SRA e do SCC.

- O impacto da hipóxia hipobárica (altas altitudes) na homeostase cardíaca. 

- Desenvolvimento de moléculas cardioprotetoras para o tratamento do infarto agudo do miocárdio.

 

 

******** PUBLICAÇÕES DO ANO DE 2025 ********

1) Souza-Silva IM, Carregari VC, Steckelings UM, Verano-Braga T. Phosphoproteomics for studying signaling pathways evoked by hormones of the renin‐angiotensin system: A source of untapped potential.

 

******** PUBLICAÇÕES DO ANO DE 2024 ********

2) Martins ALV, Annoni F, da Silva FA, Bolais-Ramos L, de Oliveira GC, Ribeiro RC, Diniz MML, Silva TGF, Pinheiro BD, Rodrigues NA, Dos Santos Matos AH, Motta-Santos D, Campagnole-Santos MJ, Verano-Braga T, Taccone FS, Santos RAS. Angiotensin-(1-7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1-2 randomized clinical trial.

3) Soares NP, Magalhaes GC, Mayrink PH, Verano-Braga T. Omics to Unveil Diabetes Mellitus Pathogenesis and Biomarkers: Focus on Proteomics, Lipidomics, and Metabolomics.

4) Raíssa-Oliveira B, Lara-Ribeiro AC, Rezende-Ribeiro J, Bahia ABQ, Verano-Braga T. Cardioproteomics: Insights on Cardiovascular Diseases.

5) da Silva Beraldo IJ, Prates Rodrigues M, Polanczyk RS, Verano-Braga T, Lopes-Aguiar C. Proteomic-Based Studies on Memory Formation in Normal and Neurodegenerative Disease-Affected Brains.

6) Rodrigues-Ribeiro L, Resende BL, Pinto Dias ML, Lopes MR, de Barros LLM, Moraes MA, Verano-Braga T, Souza BR. Neuroproteomics: Unveiling the Molecular Insights of Psychiatric Disorders with a Focus on Anxiety Disorder and Depression.

7) Netto JF, Miguez FB, Bahia SBBB, Bolais-Ramos LG, Verano-Braga T, Trigueiro JPC, Nobuyasu RS, Brandão TAS, Sousa FB. Core-sheath organic-inorganic hybrid electrospun fibers for organophosphorus heterogeneous catalysis.

 

******** PUBLICAÇÕES DO ANO DE 2023 ********

8) Verano-Braga T, Mervaala E, Santos R, Bader M. Cardiovascular Peptide Hormones – Special edition.

 

******** PUBLICAÇÕES DO ANO DE 2022 ********

9) Souza-Silva IM, de Paula CA, Bolais-Ramos L, (...), Verano-Braga T. Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors.

10) Peluso A, Kempf S, Verano-Braga T, Rodrigues-Ribeiro R et al. Quantitative Phosphoproteomics of the Angiotensin AT2-Receptor Signaling Network Identifies HDAC1 and p53 as Mediators of Anti-Proliferation and Apoptosis.

11) Silva FA, Rodrigues-Ribeiro L, Melo-Braga M, (...), Verano-Braga T, Santos RA. Phosphoproteomic studies of alamandine signaling in CHO-MrgD and human pancreatic carcinoma cells: an antiproliferative effect is unveiled.

12) Braga FHG, Gómez-Mendoza D, Lemos R, Rodrigues-Ribeiro L, Raíssa-Oliveira B, (...), Verano-Braga T. Proteomic analysis reveals stage-specific reprogramed metabolism for the primary breast cancer cell lines MGSO-3 and MACL-1.

13) Marchi FC; Mendes-Silva E; Rodrigues-Ribeiro L; Bolais-Ramos LG; Verano-Braga T. Toxinology in the proteomics era: an arachnid venom proteomics review.

14) Oliveira ACS, Rezende L, Gorshkov V, Melo-Braga MN, Verano-Braga T, et al. Biological and molecular effects of Trypanosoma cruzi residence in a LAMP deficient intracellular environment.

15) Esteves B, Melo-Braga MN, Gorshkov V, Verano-Braga T, et al. Characterization of differentially abundant proteins among Leishmania (Viannia) braziliensis strains isolated from atypical or typical lesions.

16) Mendes GMM, Do Nascimento IJB, Marazzi-Diniz PH, Da Silveira IB, Itaborahy MF, Viana LE, Silva FA, Santana MF, Pinto RA, Dutra BG, Lacerda MVG, Araujo SA, Wanderley D, Vidigal PV, Diniz PH, Verano-Braga T, Santos RA, Leite MF. The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19. 

17) Oliveira IHR, Kjeldsen F, Melo-Braga MN, Verano-Braga T, de Andrade HM. Assessing the effects of Leishmania (Leishmania) infantum and L. (L.) amazonensis infections in macrophages using a quantitative proteome approach.

 

******** PUBLICAÇÕES DO ANO DE 2021 ********

18) Martins ALV, Silva FA, Bolais-Ramos L, Oliveira GC, (...), Verano-Braga T, Santos RA. Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.

19) Gómez-Mendoza D, Lara-Ribeiro AC, Verano-Braga T. Pathological cardiac remodeling seen by the eyes of proteomics.

  

******** PUBLICAÇÕES DO ANO DE 2020 ********

20) Verano-Braga T, Martins ALV, Motta-Santos D, Campagnole-Santos MJ, Santos RA. ACE2 in the Renin-Angiotensin System.

21) Gómez-Mendoza D, Lemos RP, de Jesus I, Gorshkov V, McKinnie SMK, Vederas JC, Kjeldsen F, Guatimosim S, Santos RA, Pimenta AMC, Verano-Braga T. Moving pieces in a cellular puzzle: a cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban. 

22) Parreira RC, Gómez-Mendoza D, de Jesus I, Lemos RP, Santos AK, Rezende C, Figueiredo HC, Pinto M, Kjeldsen F, Guatimosim S, Resende R, Verano-Braga T. Cardiomyocyte proteome remodeling due to isoproterenol-induced cardiac hypertrophy during the compensated phase.

23) Montandon GC, Cassoli JS, Peigneur S, Verano-Braga T, et al. GiTx1, a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): isolation, structural assessments and activity on voltage-gated ion channels.

24) Leão NM, Borges BR, Verano-Braga T, Morais JP, Santos RA, Soares DC. Mesoporous silica nanoparticles loaded with alamandine as a potential new therapy against cancer.

25) Oliveira I, Figueiredo H, Rezende C, Cunha JL, Verano-Braga T, Melo-Braga M, Andrade H. Assessing the composition of the plasma membrane of Leishmania (Leishmania) infantum and L. (L.) amazonensis using label-free proteomics.

26) Fonseca Reis I, Miguez FB, Vargas CAA, Menzonatto TG, Silva IMS, Verano-Braga T, Lopes JF, Brandao TAS, De Sousa FB. Structural and Electronic Characterization of Photo-responsive Lanthanum (III) Complex Incorporated into Electrospun Fibers for Phosphate Ester Catalysis.

27) Miguez FB, Menzonatto TG, Netto JFZ, Silva IMS, Verano-Braga T, Lopes JF, Sousa FB. Photo-dynamic and fluorescent zinc complex based on spiropyran ligand.

 

******** PUBLICAÇÕES DO ANO DE 2019 ******** 

28) Gómez-Mendoza DP, Marques FD, Melo-Braga MN, Sprenger R, Sinisterra RDM, Kjeldsen F, Santos RA, Verano-Braga T. Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4.

29) Rodrigues-Ribeiro L, Melo-Braga MN, Kjeldsen F, Gómez-Mendoza DP, Verano-Braga T. Assessment of protein extraction and digestion efficiency of well-established shotgun protocols for heart proteomics. 

30) Santos RAS, Oudit GY, Verano-Braga T, Canta G, Steckelings UM, Bader M. The Renin-Angiotensin System: Going Beyond the Classical Paradigms.

31) Tavares GC, Pereira FL, Barony GM, Rezende CP, da Silva WM, de Souza GHMF, Verano-Braga T, de Carvalho Azevedo VA, Leal CAG, Figueiredo HCP. Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach.

32) Miguez F, Reis I, Dutra L, Silva I, Verano-Braga T, Lopes JF, Sousa FB. Electronic investigation of light-induced reversible coordination of Co(II)/spiropyran complex.

 

******** PUBLICAÇÕES DO ANO DE 2018 ********

33) Verano-Braga T, Gorshkov V, Munthe S, Sørensen M, Kristensen BW, Kjeldsen F. SuperQuant-assisted comparative proteome analysis of glioblastoma subpopulations allows for identification of potential novel therapeutic targets and cell markers.

 

******** PUBLICAÇÕES DO ANO DE 2017 ********

34) Rocha-Resende C, Leão NM, de Lima ME, Santos RA, Pimenta AM, Verano-Braga T. Moving pieces in a cryptomic puzzle: cryptide from Tityus serrulatus Ts3 Nav toxin as potential agonist of muscarinic receptors.

35) Cassini-Vieira P, Felipetto M, Prado LB, Verano-Braga T, et al. Ts14 from Tityus serrulatus boosts angiogenesis and attenuates inflammation and collagen deposition in sponge-induced granulation tissue in mice.

 

******** PUBLICAÇÕES DO ANO DE 2016 ********

36) Gorshkov V, Hotta SY, Verano-Braga T, Kjeldsen F. Peptide de novo sequencing of mixture tandem mass spectra.

37) Verano-Braga T, Williamson J, Edwards AVG, et al. High -performance hybrid Orbitrap mass spectrometers for quantitative proteome analysis: Observations and implications.

38) Carregari VC, Dai J, Verano-Braga T, et al. Revealing the functional structure of a new PLA2 K49 from Bothriopsis taeniata snake venom employing automatic "de novo" sequencing using CID/HCD/ETD MS/MS analyses.

 

******** PUBLICAÇÕES DO ANO DE 2015 ********

39) Schwämmle V, Verano-Braga T, Roepstorff P. Computational and statistical methods for high-throughput analysis of post-translational modifications of proteins.

40) Verano-Braga T, Gorshkov V, Kjeldsen F. SuperQuant: A Data Processing Approach to Increase Quantitative Proteome Coverage.

 

******** PUBLICAÇÕES DO ANO DE 2014 ******** 

41) Miethling-Graff R, Rumpker R, Richter M, Verano-Braga T, et al. Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells.

42) Kryuchkov F, Verano-Braga T, Kjeldsen F. N-terminal sequence tagging using reliably determined b2 ions: a useful approach to deconvolute tandem mass spectra of co-fragmented peptides in proteomics.

43) Verano-Braga T, Miethling-Graff R, Wojdyla K, et al. Insights into the cellular response triggered by silver nanoparticles using quantitative proteomics.

44) Verano-Braga T, Roepstorff P. Giftige dyr - ven eller fjende?

 

******** PUBLICAÇÕES DO ANO DE 2013 ********

45) Halcsik E, Forni MF, Fujita A, Verano-Braga T, et al. New insights in osteogenic differentiation revealed by mass spectrometric assessment of phosphorylated substrates in murine skin mesenchymal cells.

46) Verano-Braga T, Dutra AA, León IR, et al. Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus.

47) Cassoli JS, Verano-Braga T, Oliveira JS, et al. The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide.

48) Kryuchkov F, Verano-Braga T, Hansen TA, et al. Deconvolution of mixture spectra and increased throughput of peptide identification by utilization of intensified complementary ions formed in tandem mass spectrometry.

49) Rates B, Prates MV, Verano-Braga T, et al. μ-Theraphotoxin-An1a: primary structure determination and assessment of the pharmacological activity of a promiscuous anti-insect toxin from the venom of the tarantula Acanthoscurria natalensis (Mygalomorphae, Theraphosidae). 

50) Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T, et al. Discovery and characterization of alamandine: a novel component of the renin-angiotensin system.

51) Passos-Silva DG, Verano-Braga T, Santos RA. Angiotensin-(1-7): beyond the cardio-renal actions.

52) Santos RA, Ferreira AJ, Verano-Braga T, Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system.

 

******** PUBLICAÇÕES DO ANO DE 2012 ********

53) Verano-Braga T, Melo-Braga MN, León IR, et al. Modulation of protein phosphorylation, N-glycosylation and Lys-acetylation in grape (Vitis vinifera) mesocarp and exocarp owing to Lobesia botrana infection.

54) Verano-Braga T, Schwämmle V, Sylvester M, et al. Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells.

 

******** PUBLICAÇÕES DO ANO DE 2011 ********

55) Rates B, Verano-Braga T, Santos DM, et al. From the stretcher to the pharmacy's shelf: drug leads from medically important brazilian venomous arachnid species.

56) Verano-Braga T, et al. Evaluation of post-surgical cognitive function and protein fingerprints in the cerebro-spinal fluid utilizing surface-enhanced laser desorption/ionization time-of-flight mass-spectrometry (SELDI-TOF MS) after coronary artery bypass grafting: review of proteomic analytic tools and introducing a new syndrome

 

******** PUBLICAÇÕES DO ANO DE 2010 ********

57) Verano-Braga T, Figueiredo-Rezende F, et al. Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): A new agonist of B(2) kinin receptor.

58) De Lima ME, Borges, MH, Verano-Braga T, et al. Some arachnidan peptides with potential medical application. 

 

******** PUBLICAÇÕES DO ANO DE 2008 ********

59) Verano-Braga T, Rocha-Resende C, et al. Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.

 

******** PUBLICAÇÕES DO ANO DE 2006 ********

60) Nascimento DG, Rates B, Santos DM, Verano-Braga T, et al. Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones). 

 

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